Mitochondrial Uncouplers

Sep 05

Mitochondrial Uncouplers for Fat Loss: Human Trials and What Comes Next

By Damian Williams Medical Weight Loss

Takeaways Controlled mitochondrial uncouplers like HU6 are in early human trials and show promise for reducing liver fat and body adiposity while preserving lean mass. Organ-targeted and prodrug delivery systems enhance safety by…

Testosterone Replacement Therapy

The Rise of Bioengineered Ovaries: Toward a Physiologic Alternative to HRT

Takeaways Bioengineered ovary scaffolds may one day restore hormone function more naturally than conventional HRT. These implants aim to mimic feedback loops and hormone cycles rather than deliver static doses. Clinical use remains…

Medical Weight Loss

Muscle-Preserving Combos: The Promise of Bimagrumab + GLP‑1 in Advanced Weight Management

Takeaways Bimagrumab plus GLP-1 therapy may preserve muscle while promoting near-total fat loss. Protecting lean mass improves long-term strength, metabolism, and quality of life. Functional outcomes, not just body composition, will shape future…

Medical Weight Loss

Single-Shot Incretin Gene Therapy for Obesity: RJVA-002 and the Future of Endogenous GLP-1/GIP Modulation

Takeaways RJVA-002 uses gene therapy to deliver GLP-1 and GIP directly from pancreatic beta cells in a nutrient-responsive way. Preclinical studies in obese mice show up to 30% body weight loss and improved…

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