Takeaways RJVA-002 uses gene therapy to deliver GLP-1 and GIP directly from pancreatic beta cells in a nutrient-responsive way. Preclinical studies in obese mice show up to 30% body weight loss and improved…
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Single-Shot Incretin
Single-Shot Incretin Gene Therapy for Obesity: RJVA-002 and the Future of Endogenous GLP-1/GIP Modulation
Takeaways RJVA-002 uses gene therapy to deliver GLP-1 and GIP directly from pancreatic beta cells in a nutrient-responsive way. Preclinical studies in obese mice show up to 30% body weight loss and improved…
Once-Monthly MariTide (AMG-133): New Hope in Durable Obesity Treatment
Takeaways Once-monthly MariTide led to up to 17.5% weight loss in 52 weeks, with minimal regain after stopping treatment. The drug combines GLP-1 and glucagon receptor activity, offering fat burn and appetite suppression…
GPCR-Targeted Obesity Therapies: The Next Frontier Beyond GLP-1 Drugs
Takeaways Emerging GPCR-targeted therapies could offer oral, appetite-modifying weight-loss options with fewer GI side effects. GSBR-1290 shows real human efficacy (~5–7% weight loss) and convenience, while BRP highlights non-incretin, central-acting alternatives in preclinical…
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